Speedy Grandma

Speedy Grandma is the main protagonist of the series of the same name. She was given super speed when Sonic ran past her when she was a baby.

Rivalry with SpongeBob
SpongeBob and Speedy Grandma were actually fighting once in a deleted video on DuchessDoesMemes. With SpongeBob eventually winning and killing her, it is unknown if she could come back for now.